You are here: Home About us

About us

The Transregio (TRR) 237 is an interdisciplinary research network established between the:

 

140-600_BonnUniversity of Bonn

  • Prof. Gunther Hartmann (A01)
  • Dr. Florian Schmidt (A01)
  • Dr. Beate Kümmerer (A04)
  • Prof. Martin Schlee (A04)
  • Dr. Eva Bartok (A06)
  • Prof. Eicke Latz (A11)
  • Dr. Zeinab Abdullah (B15)
  • Prof. Christian Kurts (B15)
  • Dr. Lino Teichmann (B16)
  • Prof. Natalio Garbi (B16)
  • Prof. Hiroki Kato (B22)
  • Prof. Katrin Paeschke (A23)

140-600_TUDTechnical University of Dresden

  • Prof. Axel Roers (B17)
  • Prof. Angela Rösen-Wolff (B18)
  • Dr. Rayk Behrendt (B19)
  • Prof. Claudia Günther (B20)
  • Prof. Min Ae Lee-Kirsch (B21)

140-600_LMULudwig-Maximilians-University (LMU) of Munich

  • Prof. Karl-Peter Hopfner (A05)
  • Prof. Veit Hornung (A09)
  • Prof. Karl-Klaus Conzelmann (A12)
  • Prof. Anne Krug (B14)

  • Prof. Simon Rothenfußer (B14)

 

140-600_PUMPhilipps-University of Marburg

  • Prof. Stefan Bauer (A02)

140-600_TUMTechnical University of Munich (TUM)

  • Prof. Andreas Pichlmair (A07)
  • Prof. Jürgen Ruland (A10)

140-600_MPIMax-Planck-Institute (MPI) of Biochemistry

  • Prof. Elena Conti (A08)
The center was founded in 2018 and is funded by the German Research Foundation (DFG). 

 

Scientists working in the TRR 237 are interested in gaining new insights into the molecular mechanisms involved in the defense against nucleic acids. Currently, there are 21 research projects that collaboratively address several overarching questions in the field: 

 

1) How is nucleic acid metabolism functionally connected to the nucleic acid defense system? 

2) How are the defined stress responses linked to the nucleic acid defense pathways? 

3) What are the molecular mechanisms that are involved in the link of DNA damage and repair pathways to nucleic acid defense pathways?

4) What are the molecular switches that regulate a predominant type I IFN response versus inflammasome-induced cell death? 

5) What are the pathogenic principles by which dysregulated nucleic acid immunity causes sterile inflammatory disease? 

6) How does recognition of pathogen-associated nucleic acids contribute to the initiation of an antimicrobial response, and how does dysregulation limit the resolution of infection and trigger infection-associated autoimmune phenotypes? 

7) What are the implications for antimicrobial defense against pathogens switching host species within their life cycle (e.g. insect-transmitted virus)? 

 

Overall, the results for the projects will improve the understanding of the basic principles of nucleic acid immunity and facilitate the development of new clinical treatments for several inflammatory conditions. 

 

Document Actions