Selection of publications by the Transregio 237

Pelka K, Bertheloot D, Reimer E, Phulphagar K, Schmidt SV, Christ A, Stahl R, Watson N, Miyake K, Hacohen N, Haas A, Brinkmann MM, Marshak-Rothstein A, Meissner F, Latz E. The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport. Immunity. 2018 May 15;48(5):911-922.e7. doi: 10.1016/j.immuni.2018.04.011. PMID: 29768176; PMCID: PMC6482051.

Lässig C, Lammens K, Gorenflos López JL, Michalski S, Fettscher O, Hopfner KP. Unified mechanisms for self-RNA recognition by RIG-I Singleton-Merten syndrome variants. Elife. 2018 Jul 26;7:e38958. doi: 10.7554/eLife.38958. PMID: 30047865; PMCID: PMC6086658.

Scaturro P, Stukalov A, Haas DA, Cortese M, Draganova K, Płaszczyca A, Bartenschlager R, Götz M, Pichlmair A. An orthogonal proteomic survey uncovers novel Zika virus host factors. Nature. 2018 Sep;561(7722):253-257. doi: 10.1038/s41586-018-0484-5. Epub 2018 Sep 3. PMID: 30177828.

Wuerth JD, Habjan M, Wulle J, Superti-Furga G, Pichlmair A, Weber F. NSs Protein of Sandfly Fever Sicilian Phlebovirus Counteracts Interferon (IFN) Induction by Masking the DNA-Binding Domain of IFN Regulatory Factor 3. J Virol. 2018 Nov 12;92(23):e01202-18. doi: 10.1128/JVI.01202-18. PMID: 30232186; PMCID: PMC6232482.

Zimmermann N, Wolf C, Schwenke R, Lüth A, Schmidt F, Engel K, Lee-Kirsch MA, Günther C. Assessment of Clinical Response to Janus Kinase Inhibition in Patients With Familial Chilblain Lupus and TREX1 Mutation. JAMA Dermatol. 2019 Mar 1;155(3):342-346. doi: 10.1001/jamadermatol.2018.5077. PMID: 30673078; PMCID: PMC6440279.

Albers JJ, Ammon T, Gosmann D, Audehm S, Thoene S, Winter C, Secci R, Wolf A, Stelzl A, Steiger K, Ruland J, Bassermann F, Kupatt C, Anton M, Krackhardt AM. Gene editing enables T-cell engineering to redirect antigen specificity for potent tumor rejection. Life Sci Alliance. 2019 Mar 15;2(2):e201900367. doi: 10.26508/lsa.201900367. PMID: 30877233; PMCID: PMC6421629.

Hubel P, Urban C, Bergant V, Schneider WM, Knauer B, Stukalov A, Scaturro P, Mann A, Brunotte L, Hoffmann HH, Schoggins JW, Schwemmle M, Mann M, Rice CM, Pichlmair A. A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. Nat Immunol. 2019 Apr;20(4):493-502. doi: 10.1038/s41590-019-0323-3. Epub 2019 Mar 4. PMID: 30833792.

Braun E, Hotter D, Koepke L, Zech F, Groß R, Sparrer KMJ, Müller JA, Pfaller CK, Heusinger E, Wombacher R, Sutter K, Dittmer U, Winkler M, Simmons G, Jakobsen MR, Conzelmann KK, Pöhlmann S, Münch J, Fackler OT, Kirchhoff F, Sauter D. Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins. Cell Rep. 2019 May 14;27(7):2092-2104.e10. doi: 10.1016/j.celrep.2019.04.063. PMID: 31091448.

Rosenbaum M, Gewies A, Pechloff K, Heuser C, Engleitner T, Gehring T, Hartjes L, Krebs S, Krappmann D, Kriegsmann M, Weichert W, Rad R, Kurts C, Ruland J. Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells. Nat Commun. 2019 May 28;10(1):2352. doi: 10.1038/s41467-019-10203-2. PMID: 31138793; PMCID: PMC6538646.

Luksch H, Stinson WA, Platt DJ, Qian W, Kalugotla G, Miner CA, Bennion BG, Gerbaulet A, Rösen-Wolff A, Miner JJ. STING-associated lung disease in mice relies on T cells but not type I interferon. J Allergy Clin Immunol. 2019 Jul;144(1):254-266.e8. doi: 10.1016/j.jaci.2019.01.044. Epub 2019 Feb 14. PMID: 30772497; PMCID: PMC6612314.

Soda N, Sakai N, Kato H, Takami M, Fujita T. Singleton-Merten Syndrome-like Skeletal Abnormalities in Mice with Constitutively Activated MDA5. J Immunol. 2019 Sep 1;203(5):1356-1368. doi: 10.4049/jimmunol.1900354. Epub 2019 Jul 31. PMID: 31366715.

Li K, Neumann K, Duhan V, Namineni S, Hansen AL, Wartewig T, Kurgyis Z, Holm CK, Heikenwalder M, Lang KS, Ruland J. The uric acid crystal receptor Clec12A potentiates type I interferon responses. Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18544-18549. doi: 10.1073/pnas.1821351116. Epub 2019 Aug 26. PMID: 31451663; PMCID: PMC6744871.

Obermann HL, Eberhardt I, Yu P, Kaufmann A, Bauer S. RNA-DNA hybrids and ssDNA differ in intracellular half-life and toll-like receptor 9 activation. Immunobiology. 2019 Nov;224(6):843-851. doi: 10.1016/j.imbio.2019.08.001. Epub 2019 Aug 10. PMID: 31521407.

Greulich W, Wagner M, Gaidt MM, Stafford C, Cheng Y, Linder A, Carell T, Hornung V. TLR8 Is a Sensor of RNase T2 Degradation Products. Cell. 2019 Nov 27;179(6):1264-1275.e13. doi: 10.1016/j.cell.2019.11.001. PMID: 31778653.

Gat Y, Schuller JM, Lingaraju M, Weyher E, Bonneau F, Strauss M, Murray PJ, Conti E. InsP₆ binding to PIKK kinases revealed by the cryo-EM structure of an SMG1-SMG8-SMG9 complex. Nat Struct Mol Biol. 2019 Dec;26(12):1089-1093. doi: 10.1038/s41594-019-0342-7. Epub 2019 Dec 2. PMID: 31792449.

Tüngler V, Doebler-Neumann M, Salandin M, Kaufmann P, Wolf C, Lucas N, Harmuth F, Reichbauer J, Krägeloh-Mann I, Schüle R, Lee-Kirsch MA. Aicardi-Goutières syndrome due to a paternal mosaic IFIH1 mutation. Neurol Genet. 2019 Dec 19;6(1):e384. doi: 10.1212/NXG.0000000000000384. PMID: 32042913; PMCID: PMC6936312.

Ruzicka M, Koenig LM, Formisano S, Boehmer DFR, Vick B, Heuer EM, Meinl H, Kocheise L, Zeitlhöfler M, Ahlfeld J, Kobold S, Endres S, Subklewe M, Duewell P, Schnurr M, Jeremias I, Lichtenegger FS, Rothenfusser S. RIG-I-based immunotherapy enhances survival in preclinical AML models and sensitizes AML cells to checkpoint blockade. Leukemia. 2020 Apr;34(4):1017-1026. doi: 10.1038/s41375-019-0639-x. Epub 2019 Nov 18. PMID: 31740809; PMCID: PMC721425.

de Jesus AA, Hou Y, Brooks S, Malle L, Biancotto A, Huang Y, Calvo KR, Marrero B, Moir S, Oler AJ, Deng Z, Montealegre Sanchez GA, Ahmed A, Allenspach E, Arabshahi B, Behrens E, Benseler S, Bezrodnik L, Bout-Tabaku S, Brescia AC, Brown D, Burnham JM, Caldirola MS, Carrasco R, Chan AY, Cimaz R, Dancey P, Dare J, DeGuzman M, Dimitriades V, Ferguson I, Ferguson P, Finn L, Gattorno M, Grom AA, Hanson EP, Hashkes PJ, Hedrich CM, Herzog R, Horneff G, Jerath R, Kessler E, Kim H, Kingsbury DJ, Laxer RM, Lee PY, Lee-Kirsch MA, Lewandowski L, Li S, Lilleby V, Mammadova V, Moorthy LN, Nasrullayeva G, O'Neil KM, Onel K, Ozen S, Pan N, Pillet P, Piotto DG, Punaro MG, Reiff A, Reinhardt A, Rider LG, Rivas-Chacon R, Ronis T, Rösen-Wolff A, Roth J, Ruth NM, Rygg M, Schmeling H, Schulert G, Scott C, Seminario G, Shulman A, Sivaraman V, Son MB, Stepanovskiy Y, Stringer E, Taber S, Terreri MT, Tifft C, Torgerson T, Tosi L, Van Royen-Kerkhof A, Wampler Muskardin T, Canna SW, Goldbach-Mansky R. Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases. J Clin Invest. 2020 Apr 1;130(4):1669-1682. doi: 10.1172/JCI129301. PMID: 31874111; PMCID: PMC7108905.

Ostendorf T, Zillinger T, Andryka K, Schlee-Guimaraes TM, Schmitz S, Marx S, Bayrak K, Linke R, Salgert S, Wegner J, Grasser T, Bauersachs S, Soltesz L, Hübner MP, Nastaly M, Coch C, Kettwig M, Roehl I, Henneke M, Hoerauf A, Barchet W, Gärtner J, Schlee M, Hartmann G, Bartok E. Immune Sensing of Synthetic, Bacterial, and Protozoan RNA by Toll-like Receptor 8 Requires Coordinated Processing by RNase T2 and RNase 2. Immunity. 2020 Apr 14;52(4):591-605.e6. doi: 10.1016/j.immuni.2020.03.009. PMID: 32294405.

Wolf C, Brück N, Koss S, Griep C, Kirschfink M, Palm-Beden K, Fang M, Röber N, Winkler S, Berner R, Latz E, Günther C, Lee-Kirsch MA. Janus kinase inhibition in complement component 1 deficiency. J Allergy Clin Immunol. 2020 Apr 20:S0091-6749(20)30487-5. doi: 10.1016/j.jaci.2020.04.002. Epub ahead of print. PMID: 32325142.

Sürün D, Schneider A, Mircetic J, Neumann K, Lansing F, Paszkowski-Rogacz M, Hänchen V, Lee-Kirsch MA, Buchholz F. Efficient Generation and Correction of Mutations in Human iPS Cells Utilizing mRNAs of CRISPR Base Editors and Prime Editors. Genes (Basel). 2020 May 6;11(5):511. doi: 10.3390/genes11050511. PMID: 32384610; PMCID: PMC7288465.

Huber JE, Ahlfeld J, Scheck MK, Zaucha M, Witter K, Lehmann L, Karimzadeh H, Pritsch M, Hoelscher M, von Sonnenburg F, Dick A, Barba-Spaeth G, Krug AB, Rothenfußer S, Baumjohann D. Dynamic changes in circulating T follicular helper cell composition predict neutralising antibody responses after yellow fever vaccination. Clin Transl Immunology. 2020 May 13;9(5):e1129. doi: 10.1002/cti2.1129. PMID: 32419947; PMCID: PMC7221214.

Siedel H, Roers A, Rösen-Wolff A, Luksch H. Type I interferon-independent T cell impairment in a Tmem173 N153S/WT mouse model of STING associated vasculopathy with onset in infancy (SAVI). Clin Immunol. 2020 May 27;216:108466. doi: 10.1016/j.clim.2020.108466. Epub ahead of print. PMID: 32470544.

Langer LM, Gat Y, Bonneau F, Conti E. Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity. Elife. 2020 May 29;9:e57127. doi: 10.7554/eLife.57127. Epub ahead of print. PMID: 32469312.

Lingaraju M, Schuller JM, Falk S, Gerlach P, Bonneau F, Basquin J, Benda C, Conti E. To Process or to Decay: A Mechanistic View of the Nuclear RNA Exosome. Cold Spring Harb Symp Quant Biol. 2020 Jun 3:040295. doi: 10.1101/sqb.2019.84.040295. Epub ahead of print. PMID: 32493762.

Bennion BG, Croft CA, Ai TL, Qian W, Menos AM, Miner CA, Frémond ML, Doisne JM, Andhey PS, Platt DJ, Bando JK, Wang ER, Luksch H, Molina TJ, Roberson EDO, Artyomov MN, Rösen-Wolff A, Colonna M, Rieux-Laucat F, Di Santo JP, Neven B, Miner JJ. STING Gain-of-Function Disrupts Lymph Node Organogenesis and Innate Lymphoid Cell Development in Mice. Cell Rep. 2020 Jun 16;31(11):107771. doi: 10.1016/j.celrep.2020.107771. PMID: 32553167.

Lucas N, Dückers G, Speckmann C, Ehl S, Utz N, Cheng B, Fang M, Niehues T, Lee-Kirsch MA. NAXD Deficiency Associated with Perinatal Autoinflammation, Pancytopenia, Dermatitis, Colitis, and Cystic Encephalomalacia. J Pediatric Neurol. July 2020, DOI: 10.1055/s-0040-1713682

Wuerth JD, Habjan M, Kainulainen M, Berisha B, Bertheloot D, Superti-Furga G, Pichlmair A, Weber F. eIF2B as a Target for Viral Evasion of PKR-Mediated Translation Inhibition. mBio. 2020 Jul 14;11(4):e00976-20. doi: 10.1128/mBio.00976-20. PMID: 32665273; PMCID: PMC7360930

Lauterbach MA, Latz E, Christ A. Metabolomic Profiling Reveals Distinct and Mutual Effects of Diet and Inflammation in Shaping Systemic Metabolism in Ldlr-/- Mice. Metabolites. 2020 Aug 19;10(9):336. doi: 10.3390/metabo10090336. PMID: 32824900; PMCID: PMC7570335.

Linder A, Bauernfried S, Cheng Y, Albanese M, Jung C, Keppler OT, Hornung V. CARD8 inflammasome activation triggers pyroptosis in human T cells. EMBO J. 2020 Aug 25:e105071. doi: 10.15252/embj.2020105071. Epub ahead of print. PMID: 32840892.

Sato R, Reuter T, Hiranuma R, Shibata T, Fukui R, Motoi Y, Murakami Y, Tsukamoto H, Yamazaki S, Liu K, Saitoh SI, Latz E, Miyake K. The impact of cell maturation and tissue microenvironments on the expression of endosomal Toll-like receptors in monocytes and macrophages. Int Immunol. 2020 Aug 25:dxaa055. doi: 10.1093/intimm/dxaa055. Epub ahead of print. PMID: 32840578.

Jung S, von Thülen T, Yang I, Laukemper V, Rupf B, Janga H, Panagiotidis GD, Schoen A, Nicolai M, Schulte LN, Obermann HL, Weber F, Kaufmann A, Bauer S. A ribosomal RNA fragment with 2',3'-cyclic phosphate and GTP-binding activity acts as RIG-I ligand. Nucleic Acids Res. 2020 Sep 18:gkaa739. doi: 10.1093/nar/gkaa739. Epub ahead of print. PMID: 32946572.

Abu Tayeh A, Funabiki M, Shimizu S, Satoh S, Sumin L, Iwakura Y, Kato H, Fujita T. Psoriasis-like skin disorder in transgenic mice expressing a RIG-I Singleton-Merten syndrome variant. Int Immunol. 2020 Oct 29:dxaa071. doi: 10.1093/intimm/dxaa071. Epub ahead of print. PMID: 33119735.

Michalski S, de Oliveira Mann CC, Stafford CA, Witte G, Bartho J, Lammens K, Hornung V, Hopfner KP. Structural basis for sequestration and autoinhibition of cGAS by chromatin. Nature. 2020 Nov;587(7835):678-682. doi: 10.1038/s41586-020-2748-0. Epub 2020 Sep 10. PMID: 32911480.

Schuller SK, Schuller JM, Prabu JR, Baumgärtner M, Bonneau F, Basquin J, Conti E. Structural insights into the nucleic acid remodeling mechanisms of the yeast THO-Sub2 complex. Elife. 2020 Nov 16;9:e61467. doi: 10.7554/eLife.61467. PMID: 33191913; PMCID: PMC7744097.

Szurgot I, Ljungberg K, Kümmerer BM, Liljeström P. . Infectious RNA vaccine protects mice against chikungunya virus infection. Sci Rep. 2020 Dec 3;10(1):21076. doi: 10.1038/s41598-020-78009-7. PMID: 33273501; PMCID: PMC7712826.

Aschoff R, Zimmermann N, Beissert S, Günther C. Type I Interferon Signature in Chilblain-Like Lesions Associated with the COVID-19 Pandemic. Dermatopathology (Basel). 2020 Dec 4;7(3):57-63. doi: 10.3390/dermatopathology7030010. PMID: 33291622; PMCID: PMC7768511.

Koenig PA, Das H, Liu H, Kümmerer BM, Gohr FN, Jenster LM, Schiffelers LDJ, Tesfamariam YM, Uchima M, Wuerth JD, Gatterdam K, Ruetalo N, Christensen MH, Fandrey CI, Normann S, Tödtmann JMP, Pritzl S, Hanke L, Boos J, Yuan M, Zhu X, Schmid-Burgk JL, Kato H, Schindler M, Wilson IA, Geyer M, Ludwig KU, Hällberg BM, Wu NC, Schmidt FI. Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape. Science. 2021 Jan 12:eabe6230. doi: 10.1126/science.abe6230. Epub ahead of print. PMID: 33436526.

Hofmann J, Gadjalova I, Mishra R, Ruland J, Keppler SJ. Efficient Tissue Clearing and Multi-Organ Volumetric Imaging Enable Quantitative Visualization of Sparse Immune Cell Populations During Inflammation. Front Immunol. 2021 Jan 25;11:599495. doi: 10.3389/fimmu.2020.599495. PMID: 33569052; PMCID: PMC7869862.

Bauernfried S, Scherr MJ, Pichlmair A, Duderstadt KE, Hornung V. Human NLRP1 is a sensor for double-stranded RNA. Science. 2021 Jan 29;371(6528):eabd0811. doi: 10.1126/science.abd0811. Epub 2020 Nov 26. PMID: 33243852.

Bamborschke D, Kreutzer M, Koy A, Koerber F, Lucas N, Huenseler C, Herkenrath P, Lee-Kirsch MA, Cirak S. PNPT1 mutations may cause Aicardi-Goutières-Syndrome. Brain Dev. 2021 Feb;43(2):320-324. doi: 10.1016/j.braindev.2020.10.005. Epub 2020 Nov 4. PMID: 33158637.

Heinen A, Schnabel A, Brück N, Smitka M, Wolf C, Lucas N, Dollinger S, Hahn G, Günther C, Berner R, Lee-Kirsch MA, Schuetz C. Interferon signature guiding therapeutic decision making: ruxolitinib as first-line therapy for severe juvenile dermatomyositis? Rheumatology (Oxford). 2020 Nov 17:keaa657. doi: 10.1093/rheumatology/keaa657. Epub ahead of print. PMID: 33200187.

Alankus B, Ecker V, Vahl N, Braun M, Weichert W, Macher-Göppinger S, Gehring T, Neumayer T, Zenz T, Buchner M, Ruland J. Pathological RANK signaling in B cells drives autoimmunity and chronic lymphocytic leukemia. J Exp Med. 2021 Feb 1;218(2):e20200517. doi: 10.1084/jem.20200517. PMID: 33075129; PMCID: PMC7868734

Prado Acosta M, Goyette-Desjardins G, Scheffel J, Dudeck A, Ruland J, Lepenies B. S-Layer From Lactobacillus brevis Modulates Antigen-Presenting Cell Functions via the Mincle-Syk-Card9 Axis. Front Immunol. 2021 Mar 1;12:602067. doi: 10.3389/fimmu.2021.602067. PMID: 33732234; PMCID: PMC7957004.

Karliuk Y, Vom Hemdt A, Wieseler J, Pfeffer M, Kümmerer BM. Characterization and Vector Competence Studies of Chikungunya Virus Lacking Repetitive Motifs in the 3' Untranslated Region of the Genome. Viruses. 2021 Mar 4;13(3):403. doi: 10.3390/v13030403. PMID: 33806267; PMCID: PMC7999577.

Apel F, Andreeva L, Knackstedt LS, Streeck R, Frese CK, Goosmann C, Hopfner KP, Zychlinsky A. The cytosolic DNA sensor cGAS recognizes neutrophil extracellular traps. Sci Signal. 2021 Mar 9;14(673):eaax7942. doi: 10.1126/scisignal.aax7942. PMID: 33688080.

Onizawa H, Kato H, Kimura H, Kudo T, Soda N, Shimizu S, Funabiki M, Yagi Y, Nakamoto Y, Priller J, Nishikomori R, Heike T, Yan N, Tsujimura T, Mimori T, Fujita T. Aicardi-Goutières syndrome-like encephalitis in mutant mice with constitutively active MDA5. Int Immunol. 2021 Mar 31;33(4):225-240. doi: 10.1093/intimm/dxaa073. PMID: 33165593.

Prabakaran T, Troldborg A, Kumpunya S, Alee I, Marinković E, Windross SJ, Nandakumar R, Narita R, Zhang BC, Carstensen M, Vejvisithsakul P, Marqvorsen MHS, Iversen MB, Holm CK, Østergaard LJ, Pedersen FS, Pisitkun T, Behrendt R, Pisitkun P, Paludan SR. A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology. EBioMedicine. 2021 Apr 1;66:103314. doi: 10.1016/j.ebiom.2021.103314. Epub ahead of print. PMID: 33813142.

Hennrich AA, Sawatsky B, Santos-Mandujano R, Banda DH, Oberhuber M, Schopf A, Pfaffinger V, Wittwer K, Riedel C, Pfaller CK, Conzelmann KK. Safe and effective two-in-one replicon-and-VLP minispike vaccine for COVID-19: Protection of mice after a single immunization. PLoS Pathog. 2021 Apr 21;17(4):e1009064. doi: 10.1371/journal.ppat.1009064. PMID: 33882114; PMCID: PMC8092985.

Lainšček D, Fink T, Forstnerič V, Hafner-Bratkovič I, Orehek S, Strmšek Ž, Manček-Keber M, Pečan P, Esih H, Malenšek Š, Aupič J, Dekleva P, Plaper T, Vidmar S, Kadunc L, Benčina M, Omersa N, Anderluh G, Pojer F, Lau K, Hacker D, Correia BE, Peterhoff D, Wagner R, Bergant V, Herrmann A, Pichlmair A, Jerala R. A Nanoscaffolded Spike-RBD Vaccine Provides Protection against SARS-CoV-2 with Minimal Anti-Scaffold Response. Vaccines (Basel). 2021 Apr 27;9(5):431. doi: 10.3390/vaccines9050431. PMID: 33925446; PMCID: PMC8146944.

Linder A, Bothe V, Linder N, Schwarzlmueller P, Dahlström F, Bartenhagen C, Dugas M, Pandey D, Thorn-Seshold J, Boehmer DFR, Koenig LM, Kobold S, Schnurr M, Raedler J, Spielmann G, Karimzadeh H, Schmidt A, Endres S, Rothenfusser S. Defective Interfering Genomes and the Full-Length Viral Genome Trigger RIG-I After Infection With Vesicular Stomatitis Virus in a Replication Dependent Manner. Front Immunol. 2021 Apr 30;12:595390. doi: 10.3389/fimmu.2021.595390. PMID: 33995343; PMCID: PMC8119886.

Hayn M, Hirschenberger M, Koepke L, Nchioua R, Straub JH, Klute S, Hunszinger V, Zech F, Prelli Bozzo C, Aftab W, Christensen MH, Conzelmann C, Müller JA, Srinivasachar Badarinarayan S, Stürzel CM, Forne I, Stenger S, Conzelmann KK, Münch J, Schmidt FI, Sauter D, Imhof A, Kirchhoff F, Sparrer KMJ. Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities. Cell Rep. 2021 May 18;35(7):109126. doi: 10.1016/j.celrep.2021.109126. Epub 2021 Apr 27. PMID: 33974846; PMCID: PMC8078906.

Stukalov A, Girault V, Grass V, Karayel O, Bergant V, Urban C, Haas DA, Huang Y, Oubraham L, Wang A, Hamad MS, Piras A, Hansen FM, Tanzer MC, Paron I, Zinzula L, Engleitner T, Reinecke M, Lavacca TM, Ehmann R, Wölfel R, Jores J, Kuster B, Protzer U, Rad R, Ziebuhr J, Thiel V, Scaturro P, Mann M, Pichlmair A. Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Nature. 2021 Jun;594(7862):246-252. doi: 10.1038/s41586-021-03493-4. Epub 2021 Apr 12. PMID: 33845483.

Stadler D, Kächele M, Jones AN, Hess J, Urban C, Schneider J, Xia Y, Oswald A, Nebioglu F, Bester R, Lasitschka F, Ringelhan M, Ko C, Chou WM, Geerlof A, van de Klundert MA, Wettengel JM, Schirmacher P, Heikenwälder M, Schreiner S, Bartenschlager R, Pichlmair A, Sattler M, Unger K, Protzer U. Interferon-induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG20. EMBO Rep. 2021 Jun 4;22(6):e49568. doi: 10.15252/embr.201949568. Epub 2021 May 9. PMID: 33969602; PMCID: PMC8183418.

Griffante G, Gugliesi F, Pasquero S, Dell'Oste V, Biolatti M, Salinger AJ, Mondal S, Thompson PR, Weerapana E, Lebbink RJ, Soppe JA, Stamminger T, Girault V, Pichlmair A, Oroszlán G, Coen DM, De Andrea M, Landolfo S. Human cytomegalovirus-induced host protein citrullination is crucial for viral replication. Nat Commun. 2021 Jun 23;12(1):3910. doi: 10.1038/s41467-021-24178-6. PMID: 34162877; PMCID: PMC8222335.

Ramirez Alvarez C, Kee C, Sharma AK, Thomas L, Schmidt FI, Stanifer ML, Boulant S, Herrmann C. The endogenous cellular protease inhibitor SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severity. PLoS Pathog. 2021 Jun 28;17(6):e1009687. doi: 10.1371/journal.ppat.1009687. PMID: 34181691; PMCID: PMC8270430.

Krivega M, Stiefel CM, Karbassi S, Andersen LL, Chunduri NK, Donnelly N, Pichlmair A, Storchová Z. Genotoxic stress in constitutive trisomies induces autophagy and the innate immune response via the cGAS-STING pathway. Commun Biol. 2021 Jul 2;4(1):831. doi: 10.1038/s42003-021-02278-9. PMID: 34215848; PMCID: PMC8253785.

Jütte BB, Krollmann C, Cieslak K, Koerber RM, Boor P, Graef CM, Bartok E, Wagner M, Carell T, Landsberg J, Aymans P, Wenzel J, Brossart P, Teichmann LL. Intercellular cGAMP transmission induces innate immune activation and tissue inflammation in Trex1 deficiency. iScience. 2021 Jul 9;24(8):102833. doi: 10.1016/j.isci.2021.102833. PMID: 34368651; PMCID: PMC8326191.

Boehmer DFR, Formisano S, de Oliveira Mann CC, Mueller SA, Kluge M, Metzger P, Rohlfs M, Hörth C, Kocheise L, Lichtenthaler SF, Hopfner KP, Endres S, Rothenfusser S, Friedel CC, Duewell P, Schnurr M, Koenig LM. OAS1/RNase L executes RIG-I ligand-dependent tumor cell apoptosis. Sci Immunol. 2021 Jul 16;6(61):eabe2550. doi: 10.1126/sciimmunol.abe2550. PMID: 34272227.

Bonnekoh H, Vera C, Abad-Perez A, Radetzki S, Neuenschwander M, Specker E, Mahnke NA, Frischbutter S, Latz E, Nazaré M, Kries JV, Maurer M, Scheffel J, Krause K. Topical inflammasome inhibition with disulfiram prevents irritant contact dermatitis. Clin Transl Allergy. 2021 Jul 22;11(5):e12045. doi: 10.1002/clt2.12045. PMID: 34322217; PMCID: PMC8297992.

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Berndt N, Wolf C, Fischer K, Costa EC, Knuschke P, Zimmermann N, Schmidt F, Merkel M, Chara O, Lee-Kirsch MA, Günther C. Photosensitivity and cGAS-dependent type I IFN activation in lupus patients with TREX1 deficiency. J Invest Dermatol. 2021 Aug 13:S0022-202X(21)01686-9. doi: 10.1016/j.jid.2021.04.037. Epub ahead of print. PMID: 34400195.

Tzaridis T, Bachurski D, Liu S, Surmann K, Babatz F, Gesell Salazar M, Völker U, Hallek M, Herrlinger U, Vorberg I, Coch C, Reiners KS, Hartmann G. Extracellular Vesicle Separation Techniques Impact Results from Human Blood Samples: Considerations for Diagnostic Applications. Int J Mol Sci. 2021 Aug 26;22(17):9211. doi: 10.3390/ijms22179211. PMID: 34502122; PMCID: PMC8431127.

Oberhuber M, Schopf A, Hennrich AA, Santos-Mandujano R, Huhn AG, Seitz S, Riedel C, Conzelmann KK. Glycoproteins of Predicted Amphibian and Reptile Lyssaviruses Can Mediate Infection of Mammalian and Reptile Cells. Viruses. 2021 Aug 30;13(9):1726. doi: 10.3390/v13091726. PMID: 34578307; PMCID: PMC8473393.

Holleufer A, Winther KG, Gad HH, Ai X, Chen Y, Li L, Wei Z, Deng H, Liu J, Frederiksen NA, Simonsen B, Andersen LL, Kleigrewe K, Dalskov L, Pichlmair A, Cai H, Imler JL, Hartmann R. Two cGAS-like receptors induce antiviral immunity in Drosophila. Nature. 2021 Sep;597(7874):114-118. doi: 10.1038/s41586-021-03800-z. Epub 2021 Jul 14. PMID: 34261128.

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Elbracht M, Meyer R, Kricheldorf K, Gezer D, Thomas E, Betz B, Kurth I, Teichmann LL, Brümmendorf TH, Germing U, Isfort S, Koschmieder S. Germline variants in DNA repair genes, including BRCA1/2, may cause familial myeloproliferative neoplasms. Blood Adv. 2021 Sep 14;5(17):3373-3376. doi: 10.1182/bloodadvances.2021004811. PMID: 34477817.

Meinhardt A, Ramos PC, Dohmen RJ, Lucas N, Lee-Kirsch MA, Becker B, de Laffolie J, Cunha T, Niehues T, Salzer U, Yoshimi A, Erlacher M, Peters AMJ, Ehl S, Strahm B, Speckmann C. Curative Treatment of POMP-Related Autoinflammation and Immune Dysregulation (PRAID) by Hematopoietic Stem Cell Transplantation. J Clin Immunol. 2021 Oct;41(7):1664-1667. doi: 10.1007/s10875-021-01067-7. Epub 2021 Jun 16. PMID: 34131834.

Laudenbach BT, Krey K, Emslander Q, Andersen LL, Reim A, Scaturro P, Mundigl S, Dächert C, Manske K, Moser M, Ludwig J, Wohlleber D, Kröger A, Binder M, Pichlmair A. NUDT2 initiates viral RNA degradation by removal of 5'-phosphates. Nat Commun. 2021 Nov 25;12(1):6918. doi: 10.1038/s41467-021-27239-y. PMID: 34824277; PMCID: PMC8616924.

Pennemann FL, Mussabekova A, Urban C, Stukalov A, Andersen LL, Grass V, Lavacca TM, Holze C, Oubraham L, Benamrouche Y, Girardi E, Boulos RE, Hartmann R, Superti-Furga G, Habjan M, Imler JL, Meignin C, Pichlmair A. Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators. Nat Commun. 2021 Dec 1;12(1):7009. doi: 10.1038/s41467-021-27192-w. PMID: 34853303; PMCID: PMC8636641.

Albanese M, Ruhle A, Mittermaier J, Mejías-Pérez E, Gapp M, Linder A, Schmacke NA, Hofmann K, Hennrich AA, Levy DN, Humpe A, Conzelmann KK, Hornung V, Fackler OT, Keppler OT. Rapid, efficient and activation-neutral gene editing of polyclonal primary human resting CD4⁺ T cells allows complex functional analyses. Nat Methods. 2022 Jan;19(1):81-89. doi: 10.1038/s41592-021-01328-8. Epub 2021 Dec 23. PMID: 34949807; PMCID: PMC8748193.

Rosenbaum M, Schnalzger T, Engleitner T, Weiß C, Mishra R, Mibus C, Mitterer T, Rad R, Ruland J. MALT1 protease function in regulatory T cells induces MYC activity to promote mitochondrial function and cellular expansion. Eur J Immunol. 2022 Jan;52(1):85-95. doi: 10.1002/eji.202149355. Epub 2021 Nov 2. PMID: 34668583.

Ambike S, Cheng CC, Feuerherd M, Velkov S, Baldassi D, Afridi SQ, Porras-Gonzalez D, Wei X, Hagen P, Kneidinger N, Stoleriu MG, Grass V, Burgstaller G, Pichlmair A, Merkel OM, Ko C, Michler T. Targeting genomic SARS-CoV-2 RNA with siRNAs allows efficient inhibition of viral replication and spread. Nucleic Acids Res. 2022 Jan 11;50(1):333-349. doi: 10.1093/nar/gkab1248. PMID: 34928377; PMCID: PMC8754636.

Barrett B, Nguyen DH, Xu J, Guo K, Shetty S, Jones ST, Mickens KL, Shepard C, Roers A, Behrendt R, Wu L, Kim B, Santiago ML. SAMHD1 Promotes the Antiretroviral Adaptive Immune Response in Mice Exposed to Lipopolysaccharide. J Immunol. 2022 Jan 15;208(2):444-453. doi: 10.4049/jimmunol.2001389. Epub 2021 Dec 10. PMID: 34893529; PMCID: PMC8755609.

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Ohto T, Tayeh AA, Nishikomori R, Abe H, Hashimoto K, Baba S, Arias-Loza AP, Soda N, Satoh S, Matsuda M, Iizuka Y, Kondo T, Koseki H, Yan N, Higuchi T, Fujita T, Kato H. Intracellular virus sensor MDA5 mutation develops autoimmune myocarditis and nephritis. J Autoimmun. 2022 Feb;127:102794. doi: 10.1016/j.jaut.2022.102794. Epub 2022 Feb 12. PMID: 35168003.

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Lücke AC, Vom Hemdt A, Wieseler J, Fischer C, Feldmann M, Rothenfusser S, Drexler JF, Kümmerer BM. High-Throughput Platform for Detection of Neutralizing Antibodies Using Flavivirus Reporter Replicon Particles. Viruses. 2022 Feb 8;14(2):346. doi: 10.3390/v14020346. PMID: 35215941; PMCID: PMC8880525.

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Kögel A, Keidel A, Bonneau F, Schäfer IB, Conti E. The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism. Mol Cell. 2022 Feb 17;82(4):756-769.e8. doi: 10.1016/j.molcel.2022.01.009. Epub 2022 Feb 3. PMID: 35120588; PMCID: PMC8860381.

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Kerle IA, Jägerhuber L, Secci R, Pfarr N, Blüm P, Roesch R, Götze KS, Weichert W, Bassermann F, Ruland J, Winter C. Circulating Tumor DNA Profiling of a Diffuse Large B Cell Lymphoma Patient with Secondary Acute Myeloid Leukemia. Cancers (Basel). 2022 Mar 8;14(6):1371. doi: 10.3390/cancers14061371. PMID: 35326522; PMCID: PMC8946858.

Fischer K, Aringer M, Steininger J, Heil J, Beissert S, Abraham S, Günther C. Improvement of cutaneous inflammation and panniculitis in patients with dermatomyositis by the Janus kinase inhibitor baricitinib. Br J Dermatol. 2022 Mar 23. doi: 10.1111/bjd.21252. Epub ahead of print. PMID: 35318646.

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Serrero MC, Girault V, Weigang S, Greco TM, Ramos-Nascimento A, Anderson F, Piras A, Hickford Martinez A, Hertzog J, Binz A, Pohlmann A, Prank U, Rehwinkel J, Bauerfeind R, Cristea IM, Pichlmair A, Kochs G, Sodeik B. The interferon-inducible GTPase MxB promotes capsid disassembly and genome release of herpesviruses. Elife. 2022 Apr 27;11:e76804. doi: 10.7554/eLife.76804. PMID: 35475759; PMCID: PMC9150894.

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Groll T, Silva M, Sarker RSJ, Tschurtschenthaler M, Schnalzger T, Mogler C, Denk D, Schölch S, Schraml BU, Ruland J, Rad R, Saur D, Weichert W, Jesinghaus M, Matiasek K, Steiger K. Comparative Study of the Role of Interepithelial Mucosal Mast Cells in the Context of Intestinal Adenoma-Carcinoma Progression. Cancers (Basel). 2022 Apr 30;14(9):2248. doi: 10.3390/cancers14092248. PMID: 35565377; PMCID: PMC9105816.

Cetin Gedik K, Lamot L, Romano M, Demirkaya E, Piskin D, Torreggiani S, Adang LA, Armangue T, Barchus K, Cordova DR, Crow YJ, Dale RC, Durrant KL, Eleftheriou D, Fazzi EM, Gattorno M, Gavazzi F, Hanson EP, Lee-Kirsch MA, Montealegre Sanchez GA, Neven B, Orcesi S, Ozen S, Poli MC, Schumacher E, Tonduti D, Uss K, Aletaha D, Feldman BM, Vanderver A, Brogan PA, Goldbach-Mansky R. The 2021 European Alliance of Associations for Rheumatology/American College of Rheumatology points to consider for diagnosis and management of autoinflammatory type I interferonopathies: CANDLE/PRAAS, SAVI and AGS. Ann Rheum Dis. 2022 May;81(5):601-613. doi: 10.1136/annrheumdis-2021-221814. Epub 2022 Jan 27. PMID: 35086813; PMCID: PMC9036471.

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